Weight Loss After Stopping Omeprazole: 6 Withdrawal Signs to Consider!

PPI drugs work by attaching to the gastric acid pump, thereby inhibiting the production of acid. However, they are discontinued in some cases. One such example is when omeprazole is stopped, a person may lose weight.

When you stop taking omeprazole, are you experiencing weight loss? Or is your weight fluctuation normal?

If you are taking omeprazole for gastroesophageal reflux disease (GERD), it is likely that you will experience some withdrawal symptoms when you stop taking it. One of the most frequent is weight fluctuation. Some people may experience weight loss while others gain weight. This depends on changes in appetite.

To learn more about the long-term side effects of omeprazole, read on.

Omeprazole is an acid reducer and gastric acid blocker

Proton pump inhibitors are a class of medicines that reduce gastric acid production, and are a common treatment for stomach ulcers and gastroesophageal reflux disease (GERD). Omeprazole is one of the most well-known PPI drugs in the world.

Proton pump inhibitors, or PPIs, are often prescribed to people with acid reflux disease. PPIs are used to slow down the production of stomach acid, and prevent it from moving from the stomach into the esophagus. They work by getting attached to the pumps that produce the acid, and are used to treat:

Erosive esophagitis is acidity, ulcers are ulcers, heartburn is

The normal daily dose is 20 mg and it may take up to 4 days to act fully. To avoid any mishap, make sure to read the instructions carefully before consuming omeprazole. Moreover, it can also be used along with some antibiotics to get rid of bacteria that cause gastric ulcers.

Side effects of Omeprazole

As the benefits of being an OTC medicine are unclear, it is essential to examine the potential side effects. Although the side effects won’t be experienced by all consumers, if you experience the following persistent conditions, then it is important to consult your pharmacist or doctor.


Headache: abdominal disorders (constipation, flatulence, diarrhea)Stomachache: Feeling


There are rare side effects that may occur if you are taking omeprazole with any other medications.

Severe fatigue, hepatic disorders, severe diarrhea, and kidney problems can be the result of lupus.

Allergic Reaction to Omega 3 with Omeprazole

Although omeprazole, also known as Prilosec, is safe and effective when used as directed, some patients develop a serious form of an allergic reaction, which can cause breathing difficulties, chest tightness, swelling, and other symptoms.

Long-term omeprazole consumption may have several side effects, including

Can I stop taking omeprazole?

When you’re coming off a proton pump inhibitor (PPI), you’re likely to have some unpleasant symptoms. Unfortunately, abruptly stopping the PPI can cause you to experience acid reflux and other acidity symptoms. Hence, before you make the move, be sure to speak to your doctor about stopping the drug. This is particularly important if you’re going to do it on your own.

A question regarding how to stop taking omeprazole is certainly on your mind. The good news is, stopping omeprazole is not impossible; however, it can be hard. You’ll experience withdrawal symptoms, such as nausea, for about 1-2 weeks. To stop omeprazole, you’ll need to follow the following tips:

Reduce your daily dose. You can also decrease the dose by half. Another strategy is to avoid PPI medications. Manage your stress.

Omeprazole basically works by inhibiting the ATPase enzyme. It is almost always effective in treating acid reflux. However, the OTC drug may not work for you or it may cause serious side effects if you take it for a long time. It may be better to stop taking it if these are the case. However, you may experience some symptoms, including acid regurgitation and weight fluctuations

Common side effects when stopping omeprazole

common_side_effects when stopping omeprazole

During the taper period, drug withdrawal can have a variety of symptoms, such as indigestion and acid regurgitation. When you’re trying to taper omeprazole, your body will respond by showing discontinuation symptoms such as indigestion and acid regurgitation.

Although the most common side effects of taking omeprazole are similar to those of other proton pump inhibitors, some of the side effects are more severe than others. The root cause of most of the side effects remains the same: hypersecretion of gastric acid.

Omeprazole controls the production of acid in the stomach. As a result, your symptoms of heartburn may disappear within two to three weeks when you stop taking the drug. However, all such symptoms will disappear within two to three weeks after you stop taking omeprazole.


The biggest challenge of omeprazole withdrawal is not the symptoms, but the anxiety and panic attacks that accompany the process. Omeprazole withdrawal anxiety can also cause an increase in cytokines production and appetite loss.

Acid Regurgitation

For those with a history of GERD, the cause of acid regurgitation is similar to heartburn and dyspepsia. PPI therapy helps these people avoid acid regurgitation. PPI therapy is often used to treat GERD.


This must be surprising for you but omeprazole cessation will make you go through several prominent symptoms of acid reflux. This is because once you stop consuming it, the stomach secretes more acid than it does normally (hypersecretion) which gives rise to a burning sensation in the chest and towards the esophagus. Heartburn may last as long as 2-4 weeks after cessation.


Most people who’ve stopped taking omeprazole experience nausea, bloating, fatigue, and flu-like symptoms. Dizziness is one of the most common side effects of withdrawal. Former consumers of the drug experience dizziness immediately after stopping which decreases within 14 days. Vitamin deficiencies, such as B12, can also cause fatigue.


For reference, indigestion is a medical condition caused by gastric acid hypersecretion. It could cause the underlying symptoms of heartburn to worsen. As it is a medical condition, it might last up to a month after the problem is fixed.

Weight Loss After Stopping Omeprazole

Omeprazole, which is used to treat stomach ulcers, can cause weight loss. Sometimes, it is a result of the stomach contents bulging back into the esophagus because it is more likely to be obese.

Omeprazole is a common drug that helps prevent stomach acid from reappearing in your stomach. It can cause weight gain if you take it long-term. There are no scientific studies or research that supports the idea of a mysterious weight gain associated with omeprazole withdrawal. However, some studies do support the idea that long-term omeprazole ingestion can make you gain weight faster.

The weight loss that occurs when people stop taking proton pump inhibitors (PPIs) such as omeprazole is usually not a result of weight fluctuations. However, the changes in body weight might vary from person to person based on the nature of the withdrawal symptoms.

As you withdraw from PPI, you may experience some side effects, such as diarrhea. This may be a significant reason for your unexplained weight loss.

Long-term use of the drug Omeprazole causes weight gain, according to a study. The actual reason is unknown, but experts say that it can be due to excess food consumption. Patients should be advised against the long-term use of omeprazole for acidity or ulcers.


  • Does omeprazole cause water retention?

Answer: For your knowledge, water retention is fluid accumulation which can also be known as edema. Based on a study, 0.45% of the people consuming omeprazole experience water retention. Moreover, it is more common in older women who have been consuming the drug for less than a month.

  • What are the side effects of coming off omeprazole?

Answer: Coming off medicine is quite a difficult task because cessation is strongly associated with some aftereffects. When it comes to omeprazole, cessation initially is associated with several flu-like symptoms. The major three side effects of coming off omeprazole include heartburn, acid regurgitation, and dyspepsia. Several other aftereffects include anxiety, appetite loss, depression, abdominal disorders such as constipation and diarrhea, insomnia, and indigestion.

  • Does omeprazole slow digestion?

During this period, some people experience indigestion, bloating, constipation, diarrhea, and flatulence. This is because omeprazole causes a reduction in the amount of gastric acid produced in the stomach, which causes delayed gastric emptying, thereby altering the digestive process and taming up abdominal disorders.


Omeprazole is often used to help heal the stomach, but it comes with some serious side effects. Patients may develop a condition called Clostridium difficile (C. diff) after long-term use. This can lead to diarrhea and abdominal pain. Another side effect is B-12 deficiency. It can lead to problems with the brain and nerves. Some patients also report gastrointestinal problems, such as nausea and bloating.

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